World Health Organization (WHO) director-general Dr. Margaret Chan recently stated: "Ebola emerged nearly four decades ago. Why are clinicians still empty-handed, with no vaccines and no cure? Because Ebola has historically been confined to poor African nations. The R&D incentive is virtually non-existent. A profit-driven industry does not invest in products for markets that cannot pay." Dr. Chan noted that "My budget is highly earmarked, so it is driven by what I call donor interests."
A study in The Lancet of medical products registered in 2000-11 revealed that "Only four new chemical entities were approved for neglected diseases (three for malaria, one for diarrhoeal disease), accounting for 1% of the 336 new chemical entities approved during the study period."